“The compound SR-17018 is the first biased agonist of the mu opioid receptor that does not lead to tolerance with chronic use,” says Stahl, a senior staff scientist in the Bohn lab. “This is a desirable feature for potential use in the context of chronic, severe pain.”
Disney designed the ALS compound by applying nearly 15 years of research finding druggable structures on RNA.
A bioresponsive sensor from Carroll lab activates antioxidants only when needed and provides a tool for studying free radicals' role in disease.
The natural products collection at Scripps Florida contains hundreds of thousands of organisms available for study. Advance provides new tools for synthetic chemists and biologists looking to probe and modify sulfur-based biochemistry JUPITER, FL—A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists,…
Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in two ways, in cell studies. Njeri and Min are co-authors on the paper, published August 27, 2021, in…
The scientists have devised a way to lock HIV in its dormant stage. Now they want to throw away the key.
Mutations to Dyrk1a gene lead to brain undergrowth with features of autism and intellectual disability. An existing drug rescues the condition in newborn mice, Scripps Florida scientists find.
Study reveals how T cells in the small intestine respond to bile acids, offering localized treatment direction for a cause of chronic illness.
Scientists devise process for making precision anti-inflammatory medicines with fewer side-effects at UF Scripps Biomedical Research in Jupiter, Florida.
Disney lab at UF Scripps developed a compound that disables the replication engine of COVID-19 by disabling its viral "clutch."