Following Free Radicals With Finesse
A bioresponsive sensor from Carroll lab activates antioxidants only when needed and provides a tool for studying free radicals' role in disease.
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Inventions
Researchers Tether Cancer-Killing Natural Product to Cancer-Targeting Antibodies
A team led by chemistry professor Ben Shen, Ph.D., discovered a potent anti-cancer compound within the institute's natural products collection. It has been connected to a precise cancer-seeking antibody with an innovative linker molecule.
Mining Natural Products Reveals Nature’s Method for Building a Cancer Killer
Enediynes can bind and break DNA, leading to cell death. As a result, they have enormous potential as antibiotics and cancer drugs. A new study reveals how nature assembles them.
Scientists Look to Nature to Discover Method for Installing Sulfur Into Complex Molecules
The natural products collection at Scripps Florida contains hundreds of thousands of organisms available for study. Advance provides new tools for synthetic chemists and biologists looking to probe and modify sulfur-based biochemistry JUPITER, FL—A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists,…
Autism gene study finds widespread impact to brain’s growth signaling network
Mutations to Dyrk1a gene lead to brain undergrowth with features of autism and intellectual disability. An existing drug rescues the condition in newborn mice, Scripps Florida scientists find.
Chemists Hijack Bacterial Enzymes to Create Complex Molecules Normally Made by Plants
The three enzymes used, to construct the terpines were identified only last year, from the microbial strain collection at UF Scripps' Natural Products Discovery Center.
Once-Promising Diabetes Drugs’ Side-Effects Can be Limited, Study Finds
Altering the activity of the PPARg receptor could limit the side-effects of a useful group of diabetes drugs, TZDs.
