Nanotube tunnels that act like roadways capable of transporting cargo between cells can transmit a toxic protein linked to Huntington’s disease, a new study finds.
“The compound SR-17018 is the first biased agonist of the mu opioid receptor that does not lead to tolerance with chronic use,” says Stahl, a senior staff scientist in the Bohn lab. “This is a desirable feature for potential use in the context of chronic, severe pain.”
Disney designed the ALS compound by applying nearly 15 years of research finding druggable structures on RNA.
Rumbaugh lab found that the gene Syngap1 enables normally quiet neurons to spring into activity during sensory challenges, while other neurons are quieted.
If KIF5C is knocked out, the team found, the neurons’ ability to branch out dendrites and form input-receiving spines suffers.
Mutations to Dyrk1a gene lead to brain undergrowth with features of autism and intellectual disability. An existing drug rescues the condition in newborn mice, Scripps Florida scientists find.
GNAO1 neurodevelopmental disorders were discovered only in the past decade. Martemyanov's team at UF Scripps discovered the mechanism underlying the disorder's devastating symptoms.
Scientists shed new light on how an autism risk gene changes brain development in a way that may lead to sensory processing disorders.
Much of what we think of as memory loss is not a result of broken connections or age-related decline, but an important feature. A new study on transient forgetting from Davis lab at UF Florida sheds light on one element of this process.