“The compound SR-17018 is the first biased agonist of the mu opioid receptor that does not lead to tolerance with chronic use,” says Stahl, a senior staff scientist in the Bohn lab. “This is a desirable feature for potential use in the context of chronic, severe pain.”
Scientists at UF|Scripps have determined the near-atomic-scale structure of an unusual brain-cell receptor called GPR158, which has been linked to depression and anxiety
JUPITER, FL—The University of Florida and California-based Scripps Research have signed a definitive agreement to welcome the Florida branch of the science powerhouse into the research arm of UF’s academic health center — a step aimed at accelerating the translation of basic scientific discoveries into clinical advances that…
Disney designed the ALS compound by applying nearly 15 years of research finding druggable structures on RNA.
The natural products collection at Scripps Florida contains hundreds of thousands of organisms available for study. Advance provides new tools for synthetic chemists and biologists looking to probe and modify sulfur-based biochemistry JUPITER, FL—A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists,…
Alicia Angelbello, Ph.D., a student of the Skaggs Graduate School, studied with UF Scripps Chemistry Department Chair Matthew Disney, Ph.D. She has been awarded the American Chemical Society’s Nobel Signature Award. UF Scripps Chemist Matthew Disney and Skaggs Graduate School student Alicia Angelbello devised a way to potentially treat a…
Rumbaugh lab found that the gene Syngap1 enables normally quiet neurons to spring into activity during sensory challenges, while other neurons are quieted.
Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in two ways, in cell studies. Njeri and Min are co-authors on the paper, published August 27, 2021, in…
Like a carpenter switching drill bits depending on the job at hand, scientists at Scripps Research in Florida have changed an investigational medicine’s activity by swapping in different molecular tools, in the process, showing a potential new way to address multiple incurable diseases.
The scientists have devised a way to lock HIV in its dormant stage. Now they want to throw away the key.
