Alexander Adibekian

Alexander Adibekian,

Associate Professor

Department: The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
Business Phone: (561) 228-2740
Business Email: aadibeki@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-6453-0244

Publications

2022
Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA
Journal of the American Chemical Society. 144(26):11620-11625 [DOI] 10.1021/jacs.2c01929. [PMID] 35737519.
2022
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.
Cell chemical biology. 29(2):300-311.e10 [DOI] 10.1016/j.chembiol.2021.07.006. [PMID] 34320373.
2022
Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6.
Cell chemical biology. 29(3):530-537.e7 [DOI] 10.1016/j.chembiol.2021.07.012. [PMID] 34358442.
2022
DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC)
Journal of the American Chemical Society. 144(46):21096-21102 [DOI] 10.1021/jacs.2c07217.
2022
DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor
Proceedings of the National Academy of Sciences. 119(6) [DOI] 10.1073/pnas.2114971119. [PMID] 35110406.
2022
Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk.
International journal of molecular sciences. 23(7) [DOI] 10.3390/ijms23073959. [PMID] 35409319.
2022
Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA
ACS Chemical Biology. 17(2):474-482 [DOI] 10.1021/acschembio.1c00952. [PMID] 35044149.
2022
The Pseudo-Natural Product Rhonin Targets RHOGDI.
Angewandte Chemie (International ed. in English). 61(18) [DOI] 10.1002/anie.202115193. [PMID] 35170181.
2021
Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway
Journal of the American Chemical Society. 143(48):20332-20342 [DOI] 10.1021/jacs.1c09724.
2021
Chemoproteomics‐Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism
Angewandte Chemie. 133(6):3108-3116 [DOI] 10.1002/ange.202011163.
2021
Chemoproteomics‐Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism
Angewandte Chemie International Edition. 60(6):3071-3079 [DOI] 10.1002/anie.202011163.
2021
Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein
ACS Chemical Biology. 16(12):2845-2851 [DOI] 10.1021/acschembio.1c00756. [PMID] 34792325.
2021
Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent.
Angewandte Chemie (International ed. in English). 60(44):23750-23755 [DOI] 10.1002/anie.202108791. [PMID] 34472678.
2021
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment
Journal of the American Chemical Society. 143(33):13044-13055 [DOI] 10.1021/jacs.1c02248. [PMID] 34387474.
2021
Total Synthesis and Target Identification of the Curcusone Diterpenes
Journal of the American Chemical Society. 143(11):4379-4386 [DOI] 10.1021/jacs.1c00557. [PMID] 33705657.
2020
Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex.
Cell chemical biology. 27(5):586-597.e12 [DOI] 10.1016/j.chembiol.2020.03.008. [PMID] 32330443.
2020
Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I.
Cell chemical biology. 27(10):1318-1326.e18 [DOI] 10.1016/j.chembiol.2020.07.012. [PMID] 32763140.
2020
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions
Nature Chemistry. 12(10):952-961 [DOI] 10.1038/s41557-020-0514-4. [PMID] 32839603.
2020
Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells.
Angewandte Chemie (International ed. in English). 59(27):10961-10970 [DOI] 10.1002/anie.202002626. [PMID] 32233093.
2020
Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development.
Journal of personalized medicine. 10(4) [DOI] 10.3390/jpm10040170. [PMID] 33066497.
2020
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190.
Cell chemical biology. 27(11):1371-1382.e6 [DOI] 10.1016/j.chembiol.2020.08.007. [PMID] 32857985.
2020
S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development.
Gut. 69(10):1841-1854 [DOI] 10.1136/gutjnl-2019-319019. [PMID] 31919231.
2020
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
Proceedings of the National Academy of Sciences of the United States of America. 117(5):2406-2411 [DOI] 10.1073/pnas.1914286117. [PMID] 31964809.
2020
Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands
Journal of the American Chemical Society. 142(15):6970-6982 [DOI] 10.1021/jacs.9b13159. [PMID] 32233464.
2020
Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.
Proceedings of the National Academy of Sciences of the United States of America. 117(3):1457-1467 [DOI] 10.1073/pnas.1905057117. [PMID] 31900363.
2019
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
Nature Metabolism. 1(10):996-1008 [DOI] 10.1038/s42255-019-0123-y.
2019
A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin
Journal of the American Chemical Society. 141(7):2960-2974 [DOI] 10.1021/jacs.8b10558. [PMID] 30726072.
2019
Cover Feature: Discovery and Evaluation of New Activity‐Based Probes for Serine Hydrolases (ChemBioChem 17/2019)
ChemBioChem. 20(17):2161-2161 [DOI] 10.1002/cbic.201900493.
2019
Discovery and Evaluation of New Activity‐Based Probes for Serine Hydrolases
ChemBioChem. 20(17):2212-2216 [DOI] 10.1002/cbic.201900126.
2018
Cysteine-reactive probes and their use in chemical proteomics
Chemical Communications. 54(36):4501-4512 [DOI] 10.1039/c8cc01485j.
2018
Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids
Journal of the American Chemical Society. 140(50):17465-17473 [DOI] 10.1021/jacs.8b07652. [PMID] 30461272.
2017
Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension
ACS Central Science. 3(5):449-453 [DOI] 10.1021/acscentsci.7b00080. [PMID] 28573207.
2017
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.
Nature medicine. 23(11):1287-1297 [DOI] 10.1038/nm.4417. [PMID] 29035365.
2017
Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor
Journal of the American Chemical Society. 139(1):231-238 [DOI] 10.1021/jacs.6b09643.
2017
The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae.
Molecular biology of the cell. 28(20):2637-2649 [DOI] 10.1091/mbc.E17-03-0169. [PMID] 28768829.
2016
Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT.
Angewandte Chemie (International ed. in English). 55(8):2911-5 [DOI] 10.1002/anie.201511301. [PMID] 26798972.
2016
Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland.
ACS chemical biology. 11(4):816-20 [DOI] 10.1021/acschembio.6b00267. [PMID] 27079361.
2016
Cysteine-specific Chemical Proteomics: From Target Identification to Drug Discovery.
Chimia. 70(11):764-767 [DOI] 10.2533/chimia.2016.764. [PMID] 28661335.
2016
Divergent synthesis and identification of the cellular targets of deoxyelephantopins.
Nature communications. 7 [DOI] 10.1038/ncomms12470. [PMID] 27539788.
2015
Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules.
Angewandte Chemie (International ed. in English). 54(20):6057-61 [DOI] 10.1002/anie.201412276. [PMID] 25772490.
2015
Proteome-Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents.
Angewandte Chemie (International ed. in English). 54(37):10852-7 [DOI] 10.1002/anie.201505641. [PMID] 26211368.
2015
The 50th EUCHEM Conference on Stereochemistry (Bürgenstock Conference 2015), Brunnen, April 26th-Mai 1st, 2015.
Chimia. 69(7):485-487 [DOI] 10.2533/chimia.2015.485. [PMID] 28482982.
2014
A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice.
Nature chemical biology. 10(11):950-6 [DOI] 10.1038/nchembio.1650. [PMID] 25282505.
2014
Mechanistic effects of protein palmitoylation and the cellular consequences thereof.
Chemistry and physics of lipids. 180:44-52 [DOI] 10.1016/j.chemphyslip.2014.02.001. [PMID] 24534427.
2013
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.
The Journal of biological chemistry. 288(38):27002-27018 [DOI] 10.1074/jbc.M113.460709. [PMID] 23913689.
2013
Diced electrophoresis gel assay for screening enzymes with specified activities.
Journal of the American Chemical Society. 135(16):6002-5 [DOI] 10.1021/ja401792d. [PMID] 23581642.
2012
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes.
Journal of the American Chemical Society. 134(25):10345-8 [DOI] 10.1021/ja303400u. [PMID] 22690931.
2012
DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.
Nature chemical biology. 8(12):999-1007 [DOI] 10.1038/nchembio.1105. [PMID] 23103940.
2012
De novo chemoenzymatic synthesis of sialic acid.
Chemical communications (Cambridge, England). 48(98):11987-9 [DOI] 10.1039/c2cc37305j. [PMID] 23128386.
2011
A possible oligosaccharide-conjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic.
Chemistry & biology. 18(5):580-8 [DOI] 10.1016/j.chembiol.2011.03.009. [PMID] 21609839.
2011
Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.
Nature chemical biology. 7(7):469-78 [DOI] 10.1038/nchembio.579. [PMID] 21572424.
2011
Global profiling of dynamic protein palmitoylation.
Nature methods. 9(1):84-9 [DOI] 10.1038/nmeth.1769. [PMID] 22056678.
2010
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.
Journal of medicinal chemistry. 53(4):1830-42 [DOI] 10.1021/jm9016976. [PMID] 20099888.
2010
Chemoenzymatic synthesis of differentially protected 3-deoxysugars.
Nature chemistry. 2(2):102-5 [DOI] 10.1038/nchem.504. [PMID] 21124399.
2010
De novo synthesis of differentially protected L-iduronic acid glycosylating agents.
Carbohydrate research. 345(7):948-55 [DOI] 10.1016/j.carres.2010.02.004. [PMID] 20193949.
2010
Facile synthesis of size dependent Ru(II)-carbohydrate dendrimers via click chemistry.
Chemical communications (Cambridge, England). 46(13):2197-9 [DOI] 10.1039/b925113h. [PMID] 20234904.
2010
Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide.
Journal of the American Chemical Society. 132(30):10239-41 [DOI] 10.1021/ja104027w. [PMID] 20614885.
2010
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening.
Proceedings of the National Academy of Sciences of the United States of America. 107(49):20941-6 [DOI] 10.1073/pnas.1011663107. [PMID] 21084632.
2010
Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block.
Chemical communications (Cambridge, England). 46(23):4106-8 [DOI] 10.1039/c000784f. [PMID] 20454710.
2009
2009 Claude S. Hudson Award in Carbohydrate Chemistry. Carbohydrates: a frontier in medicinal chemistry.
Journal of medicinal chemistry. 52(18):5561-77 [DOI] 10.1021/jm900819p. [PMID] 19702275.
2009
In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots.
Journal of the American Chemical Society. 131(6):2110-2 [DOI] 10.1021/ja807711w. [PMID] 19199612.
2009
Recent advances in carbohydrate-based vaccines.
Current opinion in chemical biology. 13(3):354-9 [DOI] 10.1016/j.cbpa.2009.05.127. [PMID] 19560394.
2008
De novo synthesis of a D-galacturonic acid thioglycoside as key to the total synthesis of a glycosphingolipid from Sphingomonas yanoikuyae.
Organic letters. 10(8):1573-6 [DOI] 10.1021/ol800227b. [PMID] 18363404.
2008
Stereocontrolled synthesis of fully functionalized D-glucosamine monosaccharides via a domino nitro-Michael/Henry reaction.
Chemical communications (Cambridge, England). (30):3549-51 [DOI] 10.1039/b805159c. [PMID] 18654709.
2007
De novo synthesis of uronic acid building blocks for assembly of heparin oligosaccharides.
Chemistry (Weinheim an der Bergstrasse, Germany). 13(16):4510-22 [PMID] 17444537.
2007
Exploring the structural diversity of mammalian carbohydrates (“glycospace”) by statistical databank analysis.
ACS chemical biology. 2(10):685-91 [PMID] 18041818.
2006
Total synthesis of cyclic diterpene tonantzitlolone based on a highly stereoselective substrate-controlled aldol reaction and ring-closing metathesis.
Chemistry (Weinheim an der Bergstrasse, Germany). 12(34):8719-34 [PMID] 16955524.
2005
Short de novo synthesis of fully functionalized uronic acid monosaccharides.
Angewandte Chemie (International ed. in English). 44(46):7605-7 [PMID] 16267873.
Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G
. [DOI] 10.33774/chemrxiv-2021-2001z.
Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G
. [DOI] 10.26434/chemrxiv-2021-2001z.

Grants

Jun 2022 ACTIVE
Probing conformational changes by protein surface azidation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2022 – Jun 2022
Graduate Research Fellowship Program (GRFP) – Brendan Dwyer
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST via NATL SCIENCE FOU
Apr 2022 – May 2022
Graduate Research Fellowship Program (GRFP) – QIU
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST via NATL SCIENCE FOU
Apr 2022 – May 2022
Graduate Research Fellowship Program (GRFP) – Racioppo
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST via NATL SCIENCE FOU

Contact Details

Phones:
Business:
(561) 228-2740
Emails:
Business:
aadibeki@ufl.edu
Addresses:
Business Mailing:
Location A336
130 SCRIPPS WAY BLDG 3A1
JUPITER FL 33458
Business Street:
130 SCRIPPS WAY BLDG 3A1
JUPITER FL 33458