James Burke

James Burke,

AST PROF

Department: SR-MM-BURKE LAB
Business Phone: (561) 228-2784
Business Email: james.burke@ufl.edu

About James Burke

Publications

2022
dsRNA-induced condensation of antiviral proteins modulates PKR activity.
Proceedings of the National Academy of Sciences of the United States of America. 119(33) [DOI] 10.1073/pnas.2204235119. [PMID] 35939694.
2022
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Journal of cell science. 135(4) [DOI] 10.1242/jcs.259194. [PMID] 35098996.
2022
Regulation of ribonucleoprotein condensates by RNase L during viral infection.
Wiley interdisciplinary reviews. RNA. [DOI] 10.1002/wrna.1770. [PMID] 36479619.
2022
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granules.
The EMBO journal. 41(9) [DOI] 10.15252/embj.2021110137. [PMID] 35355287.
2022
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
PLoS pathogens. 18(11) [DOI] 10.1371/journal.ppat.1010930. [PMID] 36318584.
2021
ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms.
Journal of cell science. 134(17) [DOI] 10.1242/jcs.258783. [PMID] 34397095.
2021
Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2021.04.19.440452. [PMID] 33907748.
2021
RNase L limits host and viral protein synthesis via inhibition of mRNA export.
Science advances. 7(23) [DOI] 10.1126/sciadv.abh2479. [PMID] 34088676.
2021
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.
RNA (New York, N.Y.). 27(11):1318-1329 [DOI] 10.1261/rna.078923.121. [PMID] 34315815.
2021
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Science advances. 7(1) [DOI] 10.1126/sciadv.abd5393. [PMID] 33219112.
2020
DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity.
Genes & development. 34(23-24):1697-1712 [DOI] 10.1101/gad.340604.120. [PMID] 33184222.
2020
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
PLoS pathogens. 16(1) [DOI] 10.1371/journal.ppat.1008250. [PMID] 31905230.
2020
RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.
The Journal of biological chemistry. 295(6):1426-1438 [DOI] 10.1074/jbc.RA119.011638. [PMID] 31896577.
2019
RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs.
Molecular cell. 75(6):1203-1217.e5 [DOI] 10.1016/j.molcel.2019.07.029. [PMID] 31494035.
2018
The Murine Polyomavirus MicroRNA Locus Is Required To Promote Viruria during the Acute Phase of Infection.
Journal of virology. 92(16) [DOI] 10.1128/JVI.02131-17. [PMID] 29875236.
2017
DUSP11 – An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells.
RNA biology. 14(11):1457-1465 [DOI] 10.1080/15476286.2017.1306169. [PMID] 28296624.
2017
Expression of short hairpin RNAs using the compact architecture of retroviral microRNA genes.
Nucleic acids research. 45(17) [DOI] 10.1093/nar/gkx653. [PMID] 28973449.
2016
DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.
Genes & development. 30(18):2076-2092 [PMID] 27798849.
2015
Identification, validation, and characterization of noncanonical miRNAs.
Methods (San Diego, Calif.). 91:57-68 [DOI] 10.1016/j.ymeth.2015.07.013. [PMID] 26210399.
2014
A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA.
RNA (New York, N.Y.). 20(7):1068-77 [DOI] 10.1261/rna.044537.114. [PMID] 24854622.
2014
Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs.
Nucleic acids research. 42(22):13949-62 [DOI] 10.1093/nar/gku1247. [PMID] 25428356.
2014
Modeling test and treatment strategies for presymptomatic Alzheimer disease.
PloS one. 9(12) [DOI] 10.1371/journal.pone.0114339. [PMID] 25474698.
2014
Naturally arising strains of polyomaviruses with severely attenuated microRNA expression.
Journal of virology. 88(21):12683-93 [DOI] 10.1128/JVI.01933-14. [PMID] 25142594.
2014
The effect of pre-Affordable Care Act (ACA) Medicaid eligibility expansion in New York State on access to specialty surgical care.
Medical care. 52(9):790-5 [DOI] 10.1097/MLR.0000000000000175. [PMID] 24984209.
2013
Comprehensive mapping and analysis of Kaposi’s sarcoma-associated herpesvirus 3′ UTRs identify differential posttranscriptional control of gene expression in lytic versus latent infection.
Journal of virology. 87(23):12838-49 [DOI] 10.1128/JVI.02374-13. [PMID] 24067953.
2013
Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells.
Cell host & microbe. 14(4):435-45 [DOI] 10.1016/j.chom.2013.09.002. [PMID] 24075860.
2012
RNA virus microRNA that mimics a B-cell oncomiR.
Proceedings of the National Academy of Sciences of the United States of America. 109(8):3077-82 [DOI] 10.1073/pnas.1116107109. [PMID] 22308400.
dsRNA-induced condensation of antiviral proteins promotes PKR activation
. [DOI] 10.1101/2022.01.14.476399.
RNase L-mediated RNA decay alters 3’ end formation and splicing of host mRNAs
. [DOI] 10.1101/2022.01.28.478180.

Education

Postdoctoral Fellow
2017-2022 · University of Colorado Boulder
Ph.D.
2010-2016 · University of Texas at Austin
B.S. Biochemistry
2006-2009 · University of North Texas

Contact Details

Phones:
Business:
(561) 228-2784
Emails:
Lab Admin Coordinator III:
Veronica Padron-Schonhoff
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Addresses:
Business Street:
Location B211A
130 SCRIPPS WAY BLDG 2B2
JUPITER FL 33458