Mauricio Martins, Ph.D.
Associate Professor
Department:
SR-IM-MARTINS LAB
Business Phone:
(561) 228-3051
Business Email:
mauricio.martins@ufl.edu
Accomplishments
Vaccine’s Young Investigator
2016
·
—
Research Profile
I am interested in developing practical immune interventions against globally relevant human pathogens. HIV is the current topic of my research. My group is using rhesus macaque models of HIV/AIDS to develop active and passive immunization strategies for preventing and treating HIV infection.
Open Researcher and Contributor ID (ORCID)
0000-0001-8336-216X
Publications
2023
Adeno-associated virus-vectored delivery of HIV biologics: the promise of a “single-shot” functional cure for HIV infection
Journal of Virus Eradication.
9(1)
[DOI] 10.1016/j.jve.2023.100316.
[PMID] 36915910.
2021
Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates
Science Translational Medicine.
13(585)
[DOI] 10.1126/scitranslmed.abe3349.
[PMID] 33731434.
2021
Recombinant Herpesvirus Vectors: Durable Immune Responses and Durable Protection against Simian Immunodeficiency Virus SIVmac239 Acquisition
Journal of Virology.
95(14)
[DOI] 10.1128/jvi.00330-21.
2020
A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses
Journal of Virology.
94(2)
[DOI] 10.1128/jvi.01093-19.
2020
Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome
Journal of Virology.
94(24)
[DOI] 10.1128/jvi.00979-20.
2019
The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in
Mamu-B*08
+
Rhesus Macaques
Journal of Virology.
93(5)
[DOI] 10.1128/jvi.01626-18.
2019
Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques
PLOS Pathogens.
15(9)
[DOI] 10.1371/journal.ppat.1008015.
[PMID] 31568531.
2018
Mamu-B*17
+
Rhesus Macaques Vaccinated with
env
,
vif
, and
nef
Manifest Early Control of SIVmac239 Replication
Journal of Virology.
92(16)
[DOI] 10.1128/jvi.00690-18.
2018
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products
PLOS Pathogens.
14(6)
[DOI] 10.1371/journal.ppat.1007143.
[PMID] 29912986.
2017
Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques
Science Translational Medicine.
9(410)
[DOI] 10.1126/scitranslmed.aan8184.
[PMID] 28978754.
2017
Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques
PLOS Pathogens.
13(7)
[DOI] 10.1371/journal.ppat.1006529.
[PMID] 28732035.
Grants
Jan 2024
ACTIVE
Vectored HIV Immunotherapy via in vivo B cell editing
Role: Principal Investigator
Funding: WASHINGTON UNIV SAINT LOUIS
via NATL INST OF HLTH NIAID
Sep 2023
ACTIVE
LNP Delivery of DNA-Encoded eCD4-Ig
Role: Principal Investigator
Funding: EMMUNE
via BILL & MELINDA GATES FOUNDATION
Apr 2023
ACTIVE
An AAV-mediated functional cure and its impact on the reservoir
Role: Principal Investigator
Funding: BOSTON CHILDRENS HOSPITAL
via NATL INST OF HLTH NIAID
Dec 2022
ACTIVE
Overcoming pre-existing immunity to AAV to enhance AAV-based HIV immunotherapies
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2022
– Jun 2023
Costimulation Blockade for Preventing Anti-Drug Antibody Responses Following AAV-Mediated Gene Therapy with Anti-HIV bnAb
Role: Principal Investigator
Funding: UNIV OF MIAMI
via FL DEPT OF HLTH
Apr 2022
ACTIVE
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY
via NATL INST OF HLTH NIAID
Apr 2022
ACTIVE
AAV-mediated delivery of eCD4-Ig for prevention and treatment of perinatal HIV infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2022
ACTIVE
eCD4-Ig for preventing and treating obstetric HIV infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2022
– Feb 2023
An AAV-mediated functional cure and its impact on the reservoir
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Apr 2022
– Nov 2022
A nonhuman primate model to study the immunological effects of feminizing hormone therapy in transgender women
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Contact Details
Phones:
- Business:
- (561) 228-3051
Emails:
- Business:
- mauricio.martins@ufl.edu
Addresses:
- Business Mailing:
-
Location C221
130 SCRIPPS WAY BLDG, 2B2
JUPITER FL 33458