About Kendall Nettles
Associate Professor, Cancer Biology2005 – 2017 · Scripps Research
Open Researcher and Contributor ID (ORCID)
Activation of Crtc2/Creb1 in skeletal muscle enhances weight loss during intermittent fasting
The FASEB Journal. [DOI] 10.1096/fj.202100171r.
Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.
Organic & biomolecular chemistry. [DOI] 10.1039/c2ob26531a. [PMID] 23033157.
Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.
ChemMedChem. [DOI] 10.1002/cmdc.201200048. [PMID] 22517684.
CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
Molecular endocrinology (Baltimore, Md.). [PMID] 17932106.
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.
Chemistry & biology. [PMID] 17584613.
Partial agonists activate PPARgamma using a helix 12 independent mechanism.
Structure (London, England : 1993). [PMID] 17937915.
Structural plasticity in the oestrogen receptor ligand-binding domain.
EMBO reports. [PMID] 17468738.
Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.
Journal of medicinal chemistry. [PMID] 17228884.
Ligand control of coregulator recruitment to nuclear receptors.
Annual review of physiology. [PMID] 15709961.
A structural explanation for ERalpha/ERbeta SERM discrimination.
Ernst Schering Research Foundation workshop. [PMID] 15248503.
Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.
Molecular cell. [PMID] 14967140.
Nuclear receptor ligands and cofactor recruitment: is there a coactivator “on deck”?
Molecular cell. [PMID] 12718871.
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nature structural biology. [PMID] 11953755.
Influence of the ventral hippocampal formation on plasma vasopressin, hypothalamic-pituitary-adrenal axis, and behavioral responses to novel acoustic stress.
Brain research. [PMID] 10700613.
Anterior medial temporal lobe volumes in polydipsic schizophrenic patients with and without hypo-osmolemia: a pilot study.
Biological psychiatry. [PMID] 9347125.
Influence of the hippocampus/subiculum on antidiuretic hormone levels during stress.
Psychoneuroendocrinology. [PMID] 9044442.
Apr 2022 ACTIVE
Chemical, structural and molecular rules for fully antagonizing the estrogen receptor
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI