Matthew Pipkin

Matthew Pipkin, Ph.D.

Associate Professor

Department: SR-IM-PIPKIN LAB
Business Phone: (561) 228-2182
Business Email: m.pipkin@ufl.edu

About Matthew Pipkin

Additional Positions:
Associate Professor, Cancer Biology
2014 – 2017 · Scripps Research
Associate Professor (Joint Appointment), Immunology and Microbial Science (IMS)
2014 – 2017 · Scripps Research
Assistant Professor, Cancer Biology
2012 – 2014 · Scripps Research
Assistant Professor (Joint Appointment), Immunology and Microbial Science (IMS)
2012 – 2014 · Scripps Research

Research Profile

The overall focus of the Pipkin lab is to elucidate how chromatin structure and transcription controls the gene expression programs that establish and maintain the differentiated states of T cells. The lab specifically studies how naïve CD8 T cells differentiate into effector and memory cytotoxic T lymphocytes (CTL). CTL are killer lymphocytes that hold outstanding promise for controlling viral infections and cancer therapeutically, as they can be employed in adoptive immunotherapy and are the target of successful vaccination. The Pipkin lab has developed novel approaches to map the fundamental repeating structures of chromatin (nucleosomes) at unprecedented resolution, novel reporter genes to track cells in vivo that induce expression of Prf1, an essential gene that is required for the anti-tumor killing activity of CTL, and the only systems to conduct genome-scale pooled RNAi screens in T cells, in vivo, during the course of actual viral infections. Using these tools and approaches, the Pipkin lab is clarifying how transcription factors govern the specific organization of nucleosomes that enforces CTL differentiation, identifying the chromatin regulatory factors that maintain the differentiated state epigenetically, and demonstrating how these processes mediate durable immunity.

Grants

Apr 2022 ACTIVE
Nuclear Receptor Networks in Mucosal Immune Regulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022 ACTIVE
Elucidating the epigenetic landscape of neurofibromatosis and development of therapeutic targets
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR via NATL INST OF HLTH NINDS
Apr 2022 ACTIVE
Identification and characterization of chromatin regulators of HIV-1 latency
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID

Education

Ph.D. in Microbiology and Immunology
2005 · University of Miami, School of Medicine
Bachelor's of Science in Microbiology and Immunology
1998 · University of Miami

Contact Details

Phones:
Business:
(561) 228-2182
Emails:
Business:
m.pipkin@ufl.edu
Addresses:
Business Mailing:
120 SCRIPPS WAY
JUPITER FL 33458