About Ciaran Seath
Ciaran completed his PhD in chemistry from the University of Strathclyde in 2017 under the supervision of Dr Allan Watson studying chemoselective transition-metal catalysis. During this time he also spent time in the labs of Prof. Tom Snaddon at Indiana University working on total synthesis of complex natural products, and with Prof. Glenn Burley on the development of novel click chemistries for nucleoside bioconjugation.
He then moved to Emory University as a postdoctoral researcher working in the laboratory of Professor Nathan Jui developing novel reductive photoredox methodologies. During this time, Ciaran worked on new synthetic methods to access alkylated heterocycles and complex fluorinated scaffolds.
In 2019, Ciaran moved to Princeton University to work with Professors David MacMillan and Tom Muir where he explored new photocatalytic methods for proximity labelling to investigate critical aspects of cancer biology.
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Currently, Ciaran is an Assistant Professor of Chemistry at Scripps-UF in Jupiter, Florida.
Related Links:
Research Profile
A critical component of the development of new medicines is the identification and validation of new protein targets. Our laboratory is focused on using state-of the-art methods in chemical biology to discover new therapeutically relevant protein-biomolecule interactions that contribute to disease.
Areas of Interest
- Biochemistry and Cell Biology
- Clinical and translational science
- Pediatric brain tumors
Publications
2024
Creative approaches using proximity labeling to gain new biological insights.
Trends in biochemical sciences.
49(3):224-235
[DOI] 10.1016/j.tibs.2023.12.005.
[PMID] 38160064.
2023
Proximity labelling to study chromatin interactomes.
Nature reviews. Cancer.
23(9)
[DOI] 10.1038/s41568-023-00596-0.
[PMID] 37322270.
2023
Tracking chromatin state changes using nanoscale photo-proximity labelling.
Nature.
616(7957):574-580
[DOI] 10.1038/s41586-023-05914-y.
[PMID] 37020029.
2023
μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping.
Journal of the American Chemical Society.
145(30):16289-16296
[DOI] 10.1021/jacs.3c03325.
[PMID] 37471577.
2022
Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis.
Chemical reviews.
122(2):1485-1542
[DOI] 10.1021/acs.chemrev.1c00383.
[PMID] 34793128.
2022
Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport.
Journal of the American Chemical Society.
144(51):23633-23641
[DOI] 10.1021/jacs.2c11094.
[PMID] 36525649.
2022
Radius measurement via super-resolution microscopy enables the development of a variable radii proximity labeling platform.
Proceedings of the National Academy of Sciences of the United States of America.
119(32)
[DOI] 10.1073/pnas.2203027119.
[PMID] 35914173.
2022
Small molecule photocatalysis enables drug target identification via energy transfer.
Proceedings of the National Academy of Sciences of the United States of America.
119(34)
[DOI] 10.1073/pnas.2208077119.
[PMID] 35969791.
2022
μMap-Red: Proximity Labeling by Red Light Photocatalysis.
Journal of the American Chemical Society.
144(14):6154-6162
[DOI] 10.1021/jacs.2c01384.
[PMID] 35363468.
2021
Reactive intermediates for interactome mapping.
Chemical Society reviews.
50(5):2911-2926
[DOI] 10.1039/d0cs01366h.
[PMID] 33458734.
2019
Catalytic Strategy for Regioselective Arylethylamine Synthesis.
Journal of the American Chemical Society.
141(9):4147-4153
[DOI] 10.1021/jacs.9b01077.
[PMID] 30759339.
2019
Intermolecular Reactions of Pyridyl Radicals with Olefins via Photoredox Catalysis.
Synlett : accounts and rapid communications in synthetic organic chemistry.
30(14):1607-1614
[DOI] 10.1055/s-0037-1611527.
[PMID] 31938012.
2019
Selective C-F Functionalization of Unactivated Trifluoromethylarenes.
Journal of the American Chemical Society.
141(33):13203-13211
[DOI] 10.1021/jacs.9b06004.
[PMID] 31369264.
2018
Interrogating Pd(II) Anion Metathesis Using a Bifunctional Chemical Probe: A Transmetalation Switch.
Journal of the American Chemical Society.
140(1):126-130
[DOI] 10.1021/jacs.7b11180.
[PMID] 29257859.
2018
Radical Hydroarylation of Functionalized Olefins and Mechanistic Investigation of Photocatalytic Pyridyl Radical Reactions.
Journal of the American Chemical Society.
140(45):15525-15534
[DOI] 10.1021/jacs.8b10238.
[PMID] 30354095.
2017
A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system.
Chemical communications (Cambridge, England).
53(65):9139-9142
[DOI] 10.1039/c7cc05416e.
[PMID] 28762401.
2017
Determining the Origin of Rate-Independent Chemoselectivity in CuAAC Reactions: An Alkyne-Specific Shift in Rate-Determining Step.
Angewandte Chemie (International ed. in English).
56(12):3314-3318
[DOI] 10.1002/anie.201612288.
[PMID] 28206700.
2017
Strategy for Conditional Orthogonal Sequential CuAAC Reactions Using a Protected Aromatic Ynamine.
The Journal of organic chemistry.
82(10):5461-5468
[DOI] 10.1021/acs.joc.7b00545.
[PMID] 28452225.
2016
Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine.
Organic letters.
18(9)
[DOI] 10.1021/acs.orglett.6b01021.
[PMID] 27090999.
2016
Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine.
Organic letters.
18(7):1694-7
[DOI] 10.1021/acs.orglett.6b00635.
[PMID] 27001375.
2016
Synthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(i)/Pd(0)/Cu(ii) cascade catalysis of 2-iodoaniline/phenols.
Chemical communications (Cambridge, England).
52(56):8703-6
[DOI] 10.1039/c6cc04554e.
[PMID] 27331350.
2015
A modular synthesis of functionalised phenols enabled by controlled boron speciation.
Organic & biomolecular chemistry.
13(10):3093-102
[DOI] 10.1039/c5ob00078e.
[PMID] 25628154.
2015
Speciation control during Suzuki-Miyaura cross-coupling of haloaryl and haloalkenyl MIDA boronic esters.
Chemistry (Weinheim an der Bergstrasse, Germany).
21(24):8951-64
[DOI] 10.1002/chem.201500970.
[PMID] 25959852.
2015
Tandem Chemoselective Suzuki-Miyaura Cross-Coupling Enabled by Nucleophile Speciation Control.
Angewandte Chemie (International ed. in English).
54(34):9976-9
[DOI] 10.1002/anie.201504297.
[PMID] 26136166.
2014
Chemoselective boronic ester synthesis by controlled speciation.
Angewandte Chemie (International ed. in English).
53(45):12077-80
[DOI] 10.1002/anie.201406714.
[PMID] 25267096.
Grants
Jan 2024
ACTIVE
Photocatalytic Generation of Siloxycarbenes for Asymmetric Organocatalysis
Role: Principal Investigator
Funding: AMER CHEMICAL SOC PETRO RES
Jul 2023
ACTIVE
Photoproximity labeling as a tool for epigenetic drug discovery
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
May 2023
ACTIVE
Mechanisms of estrogen receptor ligand signaling
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Contact Details
Phones:
- Business:
- (561) 228-2241
Addresses:
- Business Street:
-
110 SCRIPPS WAY
JUPITER FL 33458