About Srinivasa Subramaniam
Dr. Srini Subramaniam is an Associate Professor (Tenure Track.) He obtained his PhD in 2004 from the University of Heidelberg, Germany, where he worked on the molecular signaling that triggers neuronal death. At Johns Hopkins University for his postdoctoral research, he addressed the mechanisms for tissue-specific dysfunctions, focusing Huntington’s and Parkinson’s disease. Both experiences continue to inform his work at The Scripps Research Institute. His hobbies involve running, boxing and sketching.
Neurodegenerative diseases are quickly becoming one of the most significant problems facing both the scientific community and the world at large. While our ability to provide symptomatic relief has increased over the past few decades, there are currently no therapies capable of modifying or halting disease progression. Our lab focuses on identification and characterization of signaling networks in neurodegenerative diseases with a goal of developing clinical therapeutics. While many of the inciting insults that cause disease are known, the complex, downstream molecular networks that fail to bring neurons back into homeostasis are poorly understood. This complexity is perhaps best characterized by our paucity of understanding in how different neurogenerative diseases have divergent neuropathologies. For example, Alzheimer’s disease (AD) causes profound deficits in hippocampal neurons; Parkinson disease (PD) patients lose neurons in the substantia nigra; and Huntington disease (HD) patients exhibit nearly complete loss of striatal neurons. Our focus is on understanding the signaling networks that mediate this phenomenon of selective vulnerability. We employ a variety of techniques to study protein-protein interactions, posttranslational modifications and signaling pathways. By elucidating the molecular mechanisms of downstream, etiology-relevant signaling pathways, we hope to discover drug-able target genes and eventually develop novel therapeutics.
Our areas of research include:
• Signaling mechanisms mediating striatal damage in HD
• Signaling mechanisms mediating abnormal movements in PD
• Novel modulators of AD pathogenesis