Mark S Sundrud

Mark S Sundrud, Ph.D.

Professor

Department: SR-IM-SUNDRUD LAB
Business Phone: (561) 228-2328
Business Email: msundrud@ufl.edu

About Mark S Sundrud

Additional Positions:
Assistant Professor, Immunology and Microbiology
2017 – 2018 · Scripps Research
Assistant Professor (Joint Appointment), Molecular Medicine
2017 – 2018 · Scripps Research
Assistant Professor, Cancer Biology
2013 – 2017 · Scripps Research

Publications

2021
CAR directs T cell adaptation to bile acids in the small intestine.
Nature. 593(7857):147-151 [DOI] 10.1038/s41586-021-03421-6. [PMID] 33828301.
2021
Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders.
Nature communications. 12(1) [DOI] 10.1038/s41467-020-20385-9. [PMID] 33397953.
2020
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America. 117(16):8900-8911 [DOI] 10.1073/pnas.1913788117. [PMID] 32253314.
2020
Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-60900-y. [PMID] 32193395.
2020
Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.
The Journal of experimental medicine. 217(5) [DOI] 10.1084/jem.20191388. [PMID] 32302378.
2020
Regulation of Intestinal Inflammation by Dietary Fats.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.604989. [PMID] 33603741.
2020
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity. 52(3) [DOI] 10.1016/j.immuni.2020.01.019. [PMID] 32187521.
2019
Emerging roles of bile acids in mucosal immunity and inflammation.
Mucosal immunology. 12(4):851-861 [DOI] 10.1038/s41385-019-0162-4. [PMID] 30952999.
2019
What’s old is new again: Batf transcription factors and Th9 cells.
Mucosal immunology. 12(3):583-585 [DOI] 10.1038/s41385-019-0155-3. [PMID] 30833634.
2018
Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma.
The Journal of investigative dermatology. 138(5):1116-1125 [DOI] 10.1016/j.jid.2017.10.028. [PMID] 29128259.
2018
Xenobiotic and endobiotic handling by the mucosal immune system.
Current opinion in gastroenterology. 34(6):404-412 [DOI] 10.1097/MOG.0000000000000478. [PMID] 30299289.
2017
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity. 47(6):1182-1196.e10 [DOI] 10.1016/j.immuni.2017.11.012. [PMID] 29262351.
2016
Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases.
Inflammatory bowel diseases. 22(5):1157-67 [DOI] 10.1097/MIB.0000000000000714. [PMID] 26863267.
2016
Informatics-Based Discovery of Disease-Associated Immune Profiles.
PloS one. 11(9) [DOI] 10.1371/journal.pone.0163305. [PMID] 27669154.
2015
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Cancer research. 75(2):296-305 [DOI] 10.1158/0008-5472.CAN-14-2277. [PMID] 25432172.
2015
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.
Immunology. 145(3):347-56 [DOI] 10.1111/imm.12444. [PMID] 25604624.
2014
Drug-resistant Th17 cells: culprits in steroid-refractory Crohn’s disease?
Immunotherapy. 6(5):503-6 [DOI] 10.2217/imt.14.30. [PMID] 24896619.
2014
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.
Journal of immunology (Baltimore, Md. : 1950). 192(5):2167-76 [DOI] 10.4049/jimmunol.1302316. [PMID] 24489094.
2014
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950). 192(6):2564-75 [DOI] 10.4049/jimmunol.1302190. [PMID] 24516202.
2014
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.
The Journal of experimental medicine. 211(1):89-104 [DOI] 10.1084/jem.20130301. [PMID] 24395888.
2014
SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells.
Journal of leukocyte biology. 95(3):521-30 [DOI] 10.1189/jlb.0613331. [PMID] 24249741.
2014
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Immunity. 40(4):477-89 [DOI] 10.1016/j.immuni.2014.04.004. [PMID] 24745332.
2014
Targeting Th17 cells in autoimmune diseases.
Trends in pharmacological sciences. 35(10):493-500 [DOI] 10.1016/j.tips.2014.07.006. [PMID] 25131183.
2013
Identity crisis of Th17 cells: many forms, many functions, many questions.
Seminars in immunology. 25(4):263-72 [DOI] 10.1016/j.smim.2013.10.021. [PMID] 24239567.
2013
T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.
Journal of immunology (Baltimore, Md. : 1950). 191(6):3100-11 [DOI] 10.4049/jimmunol.1301360. [PMID] 23966625.
2012
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Nature chemical biology. 8(3):311-7 [DOI] 10.1038/nchembio.790. [PMID] 22327401.
2011
Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells.
The Journal of experimental medicine. 208(9):1875-87 [DOI] 10.1084/jem.20102516. [PMID] 21825017.
2010
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America. 107(34):15169-74 [DOI] 10.1073/pnas.1009193107. [PMID] 20696888.
2010
Synergistic and combinatorial control of T cell activation and differentiation by transcription factors.
Current opinion in immunology. 22(3):286-92 [DOI] 10.1016/j.coi.2010.03.006. [PMID] 20399089.
2009
Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3.
PloS one. 4(12) [DOI] 10.1371/journal.pone.0008109. [PMID] 19956618.
2009
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.
Science (New York, N.Y.). 324(5932):1334-8 [DOI] 10.1126/science.1172638. [PMID] 19498172.
2008
Orphans against autoimmunity.
Immunity. 29(2):167-8 [DOI] 10.1016/j.immuni.2008.07.008. [PMID] 18701076.
2008
Regulation of T helper 17 differentiation by orphan nuclear receptors: it’s not just ROR gamma t anymore.
Immunity. 28(1):5-7 [DOI] 10.1016/j.immuni.2007.12.006. [PMID] 18199410.
2007
Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets.
Journal of immunology (Baltimore, Md. : 1950). 179(8):5433-40 [PMID] 17911630.
2007
New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT.
Current opinion in immunology. 19(3):287-93 [PMID] 17433870.
2007
Regulatory T-cell gene expression: ChIP’ing away at Foxp3.
Immunology and cell biology. 85(3):177-8 [PMID] 17353928.
2007
Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT.
Trends in immunology. 28(8):329-32 [PMID] 17618833.
2006
Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells.
Journal of virology. 80(23):11767-75 [PMID] 17005643.
2006
Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.
PloS one. 1 [PMID] 17183680.
2005
Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells.
Blood. 106(10):3440-8 [PMID] 16091457.
2004
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells.
PLoS biology. 2(7) [PMID] 15252446.
2004
Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion.
Proceedings of the National Academy of Sciences of the United States of America. 101(20):7727-32 [PMID] 15128946.
2003
Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation.
Journal of immunology (Baltimore, Md. : 1950). 171(7):3542-9 [PMID] 14500650.

Grants

Apr 2022 ACTIVE
Nuclear Receptor Control of T Cell Function in Discrete Intestinal Microenvironments
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022 ACTIVE
Nuclear Receptor Networks in Mucosal Immune Regulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022 ACTIVE
Bile acid-dependent T cell regulation in the intestine
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022 ACTIVE
Transcript-selective translational control of Th17 cell development and function
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID

Education

Ph.D. in Microbiology and Immunology
2005 · Vanderbilt University Medical Center
Bachelor's of Science in Biology and Psychology
2000 · Concordia College

Contact Details

Phones:
Business:
(561) 228-2328
Emails:
Business:
msundrud@ufl.edu
Addresses:
Business Mailing:
Scripps Way
Jupiter FL 33458