Mark S Sundrud, Ph.D.
Professor
About Mark S Sundrud
Additional Positions:
Assistant Professor, Immunology and Microbiology
2017 – 2018
·
Scripps Research
Assistant Professor (Joint Appointment), Molecular Medicine
2017 – 2018
·
Scripps Research
Assistant Professor, Cancer Biology
2013 – 2017
·
Scripps Research
Publications
2021
CAR directs T cell adaptation to bile acids in the small intestine.
Nature.
593(7857):147-151
[DOI] 10.1038/s41586-021-03421-6.
[PMID] 33828301.
2021
Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders.
Nature communications.
12(1)
[DOI] 10.1038/s41467-020-20385-9.
[PMID] 33397953.
2020
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America.
117(16):8900-8911
[DOI] 10.1073/pnas.1913788117.
[PMID] 32253314.
2020
Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-60900-y.
[PMID] 32193395.
2020
Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.
The Journal of experimental medicine.
217(5)
[DOI] 10.1084/jem.20191388.
[PMID] 32302378.
2020
Regulation of Intestinal Inflammation by Dietary Fats.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.604989.
[PMID] 33603741.
2020
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity.
52(3)
[DOI] 10.1016/j.immuni.2020.01.019.
[PMID] 32187521.
2019
Emerging roles of bile acids in mucosal immunity and inflammation.
Mucosal immunology.
12(4):851-861
[DOI] 10.1038/s41385-019-0162-4.
[PMID] 30952999.
2019
What’s old is new again: Batf transcription factors and Th9 cells.
Mucosal immunology.
12(3):583-585
[DOI] 10.1038/s41385-019-0155-3.
[PMID] 30833634.
2018
Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma.
The Journal of investigative dermatology.
138(5):1116-1125
[DOI] 10.1016/j.jid.2017.10.028.
[PMID] 29128259.
2018
Xenobiotic and endobiotic handling by the mucosal immune system.
Current opinion in gastroenterology.
34(6):404-412
[DOI] 10.1097/MOG.0000000000000478.
[PMID] 30299289.
2017
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity.
47(6):1182-1196.e10
[DOI] 10.1016/j.immuni.2017.11.012.
[PMID] 29262351.
2016
Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases.
Inflammatory bowel diseases.
22(5):1157-67
[DOI] 10.1097/MIB.0000000000000714.
[PMID] 26863267.
2016
Informatics-Based Discovery of Disease-Associated Immune Profiles.
PloS one.
11(9)
[DOI] 10.1371/journal.pone.0163305.
[PMID] 27669154.
2015
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Cancer research.
75(2):296-305
[DOI] 10.1158/0008-5472.CAN-14-2277.
[PMID] 25432172.
2015
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.
Immunology.
145(3):347-56
[DOI] 10.1111/imm.12444.
[PMID] 25604624.
2014
Drug-resistant Th17 cells: culprits in steroid-refractory Crohn’s disease?
Immunotherapy.
6(5):503-6
[DOI] 10.2217/imt.14.30.
[PMID] 24896619.
2014
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.
Journal of immunology (Baltimore, Md. : 1950).
192(5):2167-76
[DOI] 10.4049/jimmunol.1302316.
[PMID] 24489094.
2014
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950).
192(6):2564-75
[DOI] 10.4049/jimmunol.1302190.
[PMID] 24516202.
2014
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.
The Journal of experimental medicine.
211(1):89-104
[DOI] 10.1084/jem.20130301.
[PMID] 24395888.
2014
SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells.
Journal of leukocyte biology.
95(3):521-30
[DOI] 10.1189/jlb.0613331.
[PMID] 24249741.
2014
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Immunity.
40(4):477-89
[DOI] 10.1016/j.immuni.2014.04.004.
[PMID] 24745332.
2014
Targeting Th17 cells in autoimmune diseases.
Trends in pharmacological sciences.
35(10):493-500
[DOI] 10.1016/j.tips.2014.07.006.
[PMID] 25131183.
2013
Identity crisis of Th17 cells: many forms, many functions, many questions.
Seminars in immunology.
25(4):263-72
[DOI] 10.1016/j.smim.2013.10.021.
[PMID] 24239567.
2013
T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.
Journal of immunology (Baltimore, Md. : 1950).
191(6):3100-11
[DOI] 10.4049/jimmunol.1301360.
[PMID] 23966625.
2012
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Nature chemical biology.
8(3):311-7
[DOI] 10.1038/nchembio.790.
[PMID] 22327401.
2011
Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells.
The Journal of experimental medicine.
208(9):1875-87
[DOI] 10.1084/jem.20102516.
[PMID] 21825017.
2010
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America.
107(34):15169-74
[DOI] 10.1073/pnas.1009193107.
[PMID] 20696888.
2010
Synergistic and combinatorial control of T cell activation and differentiation by transcription factors.
Current opinion in immunology.
22(3):286-92
[DOI] 10.1016/j.coi.2010.03.006.
[PMID] 20399089.
2009
Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3.
PloS one.
4(12)
[DOI] 10.1371/journal.pone.0008109.
[PMID] 19956618.
2009
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.
Science (New York, N.Y.).
324(5932):1334-8
[DOI] 10.1126/science.1172638.
[PMID] 19498172.
2008
Orphans against autoimmunity.
Immunity.
29(2):167-8
[DOI] 10.1016/j.immuni.2008.07.008.
[PMID] 18701076.
2008
Regulation of T helper 17 differentiation by orphan nuclear receptors: it’s not just ROR gamma t anymore.
Immunity.
28(1):5-7
[DOI] 10.1016/j.immuni.2007.12.006.
[PMID] 18199410.
2007
Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets.
Journal of immunology (Baltimore, Md. : 1950).
179(8):5433-40
[PMID] 17911630.
2007
New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT.
Current opinion in immunology.
19(3):287-93
[PMID] 17433870.
2007
Regulatory T-cell gene expression: ChIP’ing away at Foxp3.
Immunology and cell biology.
85(3):177-8
[PMID] 17353928.
2007
Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT.
Trends in immunology.
28(8):329-32
[PMID] 17618833.
2006
Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells.
Journal of virology.
80(23):11767-75
[PMID] 17005643.
2006
Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.
PloS one.
1
[PMID] 17183680.
2005
Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells.
Blood.
106(10):3440-8
[PMID] 16091457.
2004
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells.
PLoS biology.
2(7)
[PMID] 15252446.
2004
Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion.
Proceedings of the National Academy of Sciences of the United States of America.
101(20):7727-32
[PMID] 15128946.
2003
Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation.
Journal of immunology (Baltimore, Md. : 1950).
171(7):3542-9
[PMID] 14500650.
Grants
Apr 2022
ACTIVE
Nuclear Receptor Control of T Cell Function in Discrete Intestinal Microenvironments
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022
ACTIVE
Nuclear Receptor Networks in Mucosal Immune Regulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022
ACTIVE
Bile acid-dependent T cell regulation in the intestine
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2022
ACTIVE
Transcript-selective translational control of Th17 cell development and function
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Education
Ph.D. in Microbiology and Immunology
2005
·
Vanderbilt University Medical Center
Bachelor's of Science in Biology and Psychology
2000
·
Concordia College
Contact Details
Phones:
- Business:
- (561) 228-2328
Emails:
- Business:
- msundrud@ufl.edu
Addresses:
- Business Mailing:
-
Scripps Way
Jupiter FL 33458